John Clayton Kille, son of Isaac and Martha Clayton Kille, went by his middle name of Clayton. He and his first wife, Elizabeth Cleaver, daughter of Isaac and Jemima Draper Cleaver, married in Salem County, NJ, on 21 Oct. 1802. For about a year they lived in Philadelphia, then moved to DE, where Clayton worked on several farms. In May, 1818, they began a 16 day trek to Pittsburgh, and located at a place near Chartiers Creek, four miles west of Pittsburgh. In the spring, 1819, Clayton went to Salem, OH, where his uncle, Samuel Davis, helped him find a farm to rent in Lexington Township, Stark County, OH, and by 1820, Clayton moved his family there. His wife, Elizabeth, pregnant with their eighth child, died, 27 Sep. 1820 from fever. The next year Clayton requested membership for himself and his minor children in the Deer Creek Meeting, which was a part of the Marlboro Monthly Meeting of Quakers. He married his second wife, Rebecca Coppock, a daughter of Isaac and Eleanor Coppock, in Springfield [Damascus], OH, on 3 Apr. 1823. In the spring, 1826, Clayton bought 80 acres in Smith Township, Columbiana County [Now Mahoning County], OH, moved his family there and joined the Upper Springfield Monthly Meeting. Close to a year after his wife, Rebecca's death, in the winter of 1834, Clayton lost his left eye when a colt kicked the side of his face, leaving him for his remaining years to always wear a little green silk pad over the sunken lid. Clayton married his third wife, Mary Rawls Butler, in the Marlboro OH Quaker Meetinghouse, on 7 Dec. 1836. Clayton sold his farm in Smith Township, and moved with his family to Mary's farm, in an area that by 1919 was the northern suburb of Alliance, OH. Clayton died there, aged 73 years, 4 months and 12 days, and was laid to rest by the side of his first wife. Although remembered by his children as a stern man, who raised them to obey him, he was also remembered as being "kind and very tender" when they were sick. "Intelligent and well read," Clayton was also "hospitable and a kind neighbor."

"Once, at the close of a First Day meeting in harvest time appearances denoted a coming rain. Some Friends hastened home to care for their hay, of which several of them had more or less in the fields, but father was more conscientious. He went home, ate his dinner and sat down with his Bible to read as was his custom, not paying much attention to the rain; but after a while, taking notice, he was surprised to see the clouds passing over and while it rained all around, so little fell upon his fields that no harm was done. He accepted this as an especial providence because of his trustfulness and confidence in God." - Elizabeth [Kille] Shreve-Chambers.